Potential side effects and risks of MAVENCLAD®

Potential side effects and risks of MAVENCLAD®

Welcome back to our MAVENCLAD series.

We’re going to help you understand the potential side effects and risks of MAVENCLAD.

MAVENCLAD may cause side effects. However, not everybody gets them and the types of side effects may vary.

You may experience side effects not mentioned here and it is important that you tell your healthcare professional about them straight away. You can also tell the adveva team by calling 1-888-677-3243.

MAVENCLAD affects the immune system.

Because of this, a very common, serious side effect is a reduction in the number of lymphocytes. This is known as lymphopenia.

You will have a blood test before starting MAVENCLAD in Year 1

and 2,

and between treatment courses and thereafter.

This is so that your healthcare professional can see if your lymphocytes are in an acceptable range. If your lymphocyte count is below an accepted level, your treatment will be delayed.

MAVENCLAD is associated with an increased risk of developing the infection shingles, also known as herpes zoster. Shingles is a common serious side effect caused by a viral infection (the same virus as chickenpox).

In some cases, people can get early warning signs of shingles, including

a headache,

burning,

tingling,

numbness or itchiness of the skin,

feeling generally unwell or having a fever.

The first symptom of shingles is usually a small area or localized band of severe pain,

followed by a rash that can develop into itchy blisters.

Tell your healthcare professional and they may be able to give you treatments to relieve the symptoms of shingles. Your healthcare professional will be monitoring you for shingles. If necessary, you will be vaccinated against shingles before starting MAVENCLAD. If you’ve been vaccinated, you must wait 6 weeks before you can begin your treatment with MAVENCLAD.

MAVENCLAD can reduce lymphocytes in your blood and increase the likelihood of infection. Because of this, you will need to watch for any signs or symptoms of an infection.

The signs of infections can include

fever,

aching,

painful muscles,

headache,

generally feeling unwell

and loss of appetite.

It is important to talk to your healthcare professional if you think you have an infection before, during or after treatment.

Because MAVENCLAD suppresses the immune system and damages DNA, a possible risk of cancer can’t be ruled out. Please follow your healthcare professional’s instructions for cancer screening.

Before you start MAVENCLAD, your healthcare professional may perform an MRI scan. This is to check for progressive multifocal leukoencephalopathy, or PML.

PML is a rare brain infection. You can read more about PML in the patient information leaflet.

Talk to your healthcare professional as soon as possible if you think your MS is getting worse or if you experience any new symptoms, such as weakness on one side of the body that gets worse, clumsiness of your arms and legs, trouble with your vision, changes in your thinking and memory that lead to confusion and personality changes. These may be symptoms of PML.

If you have any concerns about taking MAVENCLAD or think you may be experiencing a side effect, talk to your doctor, MS nurse or pharmacist.

Or you can call the adveva team at 1-888-677-3243.

 

 

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Explore possible side effects of MAVENCLAD

    

    

    

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Print and complete this wallet card and keep it handy for your healthcare team or in case of emergency

    

    

 

 

    

MAVENCLAD is a trademark of Merck KGaA, Darmstadt, Germany or its affiliates.


    


 

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