Treating your MS


Rebif can also be used for people who have experienced symptoms that are likely to be a first sign of MS (clinically isolated syndrome).

  • Your doctor would have had to rule out other reasons that could have explained the symptoms. A test using an imaging machine (magnetic resonance imaging, or MRI) would have to show at least two signs of inflammation in the central nervous system suggestive of MS.


How does Rebif work?

Rebif is known as a disease-modifying drug (DMD). Its medicinal ingredient is called interferon beta-1a, which is a form of protein that occurs naturally in the body. Interferon beta has been shown to modify the immune response, but the exact way that Rebif works in MS is unknown.


How to take Rebif

Rebif is taken by subcutaneous injection, meaning it’s injected just under the skin, three times a week. You don’t need to mix your medication because it is ready to inject.


What is the usual treatment schedule?


For clinically isolated syndrome (CIS), the recommended dose is 44 mcg three times a week.


For relapsing-remitting multiple sclerosis (RRMS), the recommended dose is 44 mcg three times a week.

  • Your doctor may reduce your dose to 22 mcg three times a week if you are not able to tolerate the higher dose.


Rebif has been carefully selected for you by your doctor according to your specific needs. It is very important to follow your doctor’s instructions, particularly about the amount and frequency of medication you are taking.


Your healthcare team can help you find ways to incorporate Rebif into your routine and keep track of your treatment plan.


What is an autoinjector?

Autoinjectors are injection devices that are designed to inject a single dose of medication. A benefit of the Rebif autoinjector – RebiSmart® – is that it hides the needle during the injection. It uses multidose cartridges, which store up to a week’s worth of medication.


You can use the autoinjector to take Rebif:

  • RebiSmart, the first and only customizable electronic autoinjector in MS


Storing Rebif

We recommend you store Rebif in a refrigerator between 2ºC and 8ºC; however, you can store it at room temperature (≤25ºC) for up to 30 days. DO NOT freeze Rebif.


For more information about the effectiveness, administration and possible side effects of Rebif, contact adveva or speak with your doctor.











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