The most common side effects associated with using Rebif are:

• Flu-like symptoms, which may include headache, fever, chills, muscle and joint pains, fatigue and nausea
• Injection site reactions, which may include redness, swelling, discolouration, inflammation, pain and skin breakdown

These symptoms are generally mild and tend to be more common at the start of treatment. They will typically decrease with continued use of Rebif.

Uncommon side effects are:

• Liver injury: Your doctor may ask you to have regular blood tests to make sure your liver is working properly. If you notice any symptoms, such as loss of appetite with malaise, fatigue, nausea, vomiting, abdominal pain or dark urine, please contact your doctor.
• Depression: If you have feelings of depression or sudden mood swings, please contact your doctor immediately.

Consult your doctor immediately if you develop multiple lesions and/or experience any break in the skin, which may be associated with swelling or drainage of fluid from the injection site.

Your physician may prescribe a pain reliever (acetaminophen or ibuprofen) or may temporarily change your dose. You should not stop or alter the medication without your doctor’s advice.

Please refer to the Rebif package insert for a full list of possible side effects. If any of these undesirable effects are severe or persist, contact your healthcare team.

Ask your healthcare professional or visit the adveva Helpful tips and training section for ways to help manage side effects.

A highly trained adveva nurse is also available 24/7 to discuss any concerns you may have.

Your Rebif Patient Brochure provides detailed treatment information, tips and tools to help you start and stay on Rebif as prescribed by your doctor. Visit the adveva Catalogue any time to order supplies free of charge.